Monday-Wednesday-Friday dosing creates relatively stable peptide presence
Vitamin b12, or cobalamin, is a cofactor the body cannot manufacture
Jamieson notes that peptides can be very helpful to manage some of the changes seen in skin as a result of hormonal shifts, such as dryness, sensitivity, and pigmentation. For women looking for a gentler alternative to retinoids (which can be too aggressive on hormonally sensitized skin), peptides in skincare offer a legitimate option
Takeaway: Potential utility for age-related sleep-wake cycle disruptions
A 2022 dose-response RCT (Yi et al., Geroscience) at 300/600/900 mg/day raised NAD+ dose-dependently with no safety issues at 60 days
However, even the most advanced research peptides can lose potency and stability if handled incorrectly